Neuroprotective Strategies for Intracerebral Hemorrhage: Trials and Translation
نویسندگان
چکیده
منابع مشابه
Neuroprotective strategies for intracerebral hemorrhage: trials and translation.
Intracerebral hemorrhage is a devastating neurological illness with few treatment options. In the past 10 years, 6 clinical trials have been completed examining the potential role that putative neuroprotective agents might play in improving outcome. Although each of these trials failed to show a benefit, animal research continues to supply the translational pipeline and 5 clinical trials evalua...
متن کاملAdvances in neuroprotective strategies: potential therapies for intracerebral hemorrhage.
Intracerebral hemorrhage (ICH) is associated with higher mortality and morbidity than any other form of stroke. However, there currently are no treatments proven to improve outcomes after ICH, and therefore, new effective therapies are urgently needed. Growing insight into ICH pathophysiology has led to the development of neuroprotective strategies that aim to improve the outcome through reduct...
متن کاملOngoing clinical trials in intracerebral hemorrhage.
ntracerebral hemorrhage (ICH) accounts for 10% to 15% of all strokes. ICH continues to impart a considerable degree of morbidity and mortality, with 30-day mortality ranging from 44% to 50%. ICH remains a devastating disease, and current treatment options lag far behind those for ischemic stroke. There are no approved therapies, which improve outcome, and treatment remains mainly supportive. De...
متن کاملNeurobiology of Disease Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage
After intracerebral hemorrhage (ICH), the brain parenchyma is exposed to blood containing red blood cells (RBCs) and consequently to its lysis products. Iron-rich hemoglobin (Hb) is the most abundant protein in RBCs. When released into the brain parenchyma during hemolysis, Hb becomes a central mediator of cytotoxicity. Our study indicates that haptoglobin (Hp), an acute-phase response protein ...
متن کاملReversal Strategies for Vitamin K Antagonists in Acute Intracerebral Hemorrhage
OBJECTIVE There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. METHODS We pooled individual ICH patient data from 16 stroke registries in...
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ژورنال
عنوان ژورنال: Stroke
سال: 2010
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.110.597476